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“The actress revealed the news on MeSsy , her MS-themed podcast she hosts with Jamie Lynn Sigler, who has MS, since March 2024.”
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“Account Welcome Manage Account Manage Print Account Sign Out Log In 'State of Shock' Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis: ‘It’s Very Confusing’ "You don't get misdiagnosed and then all of the sudden I'm better," actress says on MeSsy podcast By Kory Grow Kory Grow Contact Kory Grow on X Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis: ‘It’s Very Confusing’ Sharon Osbourne Talks Ozzy’s ‘Back to the Beginning’ Film: ‘He Went Out Like a Viking’ Alice Cooper Is Finally Ready to Tell the Truth View all posts by Kory Grow October 20, 2026 Add us as a Google Preferred Source Christina Applegate, 2023.”
“Matt Winkelmeyer/Getty Images/Critics Choice Association Five years after Christina Applegate ‘s doctors told her that she had multiple sclerosis , they’re now telling her she never had the autoimmune disorder.”
“Marwa Kaisey, who works in Cedars-Sinai Medical Center’s neurology department, spoke on the podcast saying misdiagnoses are “fairly common” since there is no single binary MS test saying whether a patient definitely has or doesn’t have the disorder.”
“She said she’s in a “state of shock” over the news, which she calls a “mindfuck.” What’s most frustrating for Applegate, though, is that she’s still has symptoms that no longer have an explanation and that she feels she accidentally misrepresented herself to those with the disorder, according to People .”
““I’ve gone through a great depression because of [the misdiagnosis],” Applegate said on MeSsy .”
“On back-to-back episodes of the podcast, Applegate explained that she took a leave of absence from the podcast in March while she processed her doctor’s news.”
““But I lost everything.”