https://www.smithsonianmag.com/smart-news/GLP-1-weight-loss-drugs-can-slow-aging-and-extend-lifespan-mouse-study-suggests-180989452/
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“GLP-1 Weight-Loss Drugs Can Slow Aging and Extend Life Span, Mouse Study Suggests Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.”
“The researchers didn’t include male mice because they are more aggressive, which could complicate the study’s findings.”
“Now, new research hints that the blockbuster drugs might have yet another benefit: slowing aging.”
“Mice given the GLP-1 also exhibited remarkable physical and cognitive abilities.”
“The median life span of saline-treated mice was 742 days, while that of semaglutide-treated mice was 834 days, a 12 percent increase.”
“Still, more testing in mice is needed, especially because the study involved only female animals.”
“But how do the effects of semaglutide compare to those of calorie restriction?”
“Trying to extend life span with semaglutide may therefore accelerate frailty, Matt Mendoza , a neuroscientist at the University of Texas Medical Branch, tells C&EN .”
“The findings suggest that semaglutide’s potential longevity benefits come from “more than just calorie restriction,” Chen tells Scientific American ’s Jacek Krywko.”
““Skeletal muscle is your largest endocrine organ,” he says.”
“LPETTET via Getty Images GLP-1 medicines like semaglutide—marketed as Ozempic and Wegovy—have become cultural sensations over the past few years.”
“They mimic a natural hormone that triggers feelings of fullness and helps regulate blood sugar .”
““One intervention that works in one gender does not necessarily generalize to another gender,” Ho Ko , a neuroscientist at the Chinese University of Hong Kong, tells Nature .”
“In the past century, scientists have realized that restricting calorie intake can extend life span, but strict diets are notoriously difficult for people to sustain.”
“Exercise is crucial to combat potential muscle loss.”
“GLP-1 Weight-Loss Drugs Can Slow Aging and Extend Life Span, Mouse Study Suggests Older female mice—equivalent in age to 60-year-old women—given daily injections of the active ingredient in Ozempic lived about 12 percent longer than animals that didn’t receive the drug Soumya Sagar | Correspondent September 4, 2026 11:16 a.m.”